Sameer Sheth, MD, PhD

Profile Headshot


Dr. Sheth graduated Summa Cum Laude from Harvard University with a degree in Physics and Astronomy. He then entered the Medical Scientist Training Program at the UCLA School of Medicine, where he received both his MD and PhD degrees. Dr. Sheth trained in Neurological Surgery at the Massachusetts General Hospital and Harvard Medical School.

Dr. Sheth specializes in the treatment of patients with Movement Disorders, Epilepsy, Brain Tumors, Trigeminal Neuralgia, Hydrocephalus, and certain Psychiatric Disorders. He enjoys bringing a personalized approach to each patient in order to arrive at an individually tailored treatment plan optimized for the patient and his or her family. He works with a world-class multi-disciplinary team of surgeons, neurologists, psychiatrists, radiologists, and others to provide compassionate, state-of-the-art care for his patients. Among the many techniques at his disposal are stereotactic neurosurgery, deep brain stimulation, ablative techniques, awake brain mapping, electrode recordings, computer-guided navigation, and microsurgery.

Dr. Sheth is also a neuroscientist, with PhD and post-doctoral training in neurophysiology. His research interests are centered on a desire to better understand brain function. Dr. Sheth’s research is motivated by the belief that if we can understand how the brain works at the level of individual neurons and circuits, we will be much better equipped to repair it. By understanding normal brain processes such as motor control, reward processing, and decision-making, we can understand disease processes such as movement disorders, addiction, and anxiety disorders. Dr. Sheth’s research has been funded by the NIH, the Harvard Catalyst, the MGH Cancer Center, and the American Association of Neurological Surgeons.

Dr. Sheth is Director and Founder of the Functional and Cognitive Neurophysiology laboratory, which focuses on the study of human decision-making, behavior, and cognitive processes.

Areas of Expertise / Conditions Treated

  • Adult Trauma
  • Anaplastic Astrocytoma
  • Arachnoid Cyst
  • Astrocytoma
  • Benign Essential Tremor
  • Biopsies
  • Brain Abscess
  • Brain Aneurysm
  • Brain Stem Glioma
  • Brain Tumor
  • Brain Tumor Surgery
  • Cavernous Malformation
  • Chiari Malformation
  • Chronic Pain
  • Computer Assisted Surgery
  • Computer Assisted Surgery (CAS)
  • Concussion
  • Craniopharyngioma Surgery
  • Craniotomy
  • Deep Brain Stimulation
  • Dystonia
  • Epilepsy
  • Epilepsy Surgery
  • Epileptic Seizures
  • Facial Pain
  • Functional Brain Mapping
  • Gamma Knife
  • Gamma Knife Radiosurgery
  • Glioblastoma Multiforme
  • Gliomas
  • Head Injury
  • Head Trauma
  • Hemangioblastoma
  • Hemifacial Spasm
  • Hydrocephalus
  • Meningioma
  • Microsurgery
  • Microvascular Decompression
  • Microvascular Neurosurgery
  • Microvascular Surgery
  • Minimally Invasive Brain Surgery
  • Minimally Invasive Neurosurgery
  • Minimally Invasive Procedures
  • Minimally Invasive Surgery
  • Minimally Invasive Techniques
  • Movement Disorder
  • Neurobehavioral Disorders
  • Neuropathic Pain
  • Neurosurgery
  • Parkinson's Disease
  • Pediatric Epilepsy
  • Pediatric Seizures
  • Seizure Disorder
  • Shunts
  • Skull Base Surgery
  • Skull Base Tumors
  • Spasticity
  • Spinal Tumors
  • Stereotactic Neurosurgery
  • Stereotactic Radiosurgery
  • Stereotactic Surgery
  • Trauma
  • Trauma Surgery
  • Traumatic Brain Injury
  • Trigeminal Neuralgia
  • Trigeminal Neuralgia Surgery

Academic Appointments

  • Assistant Professor of Neurological Surgery

Administrative Titles

  • Advisory Committee, CTNI
  • Unit Director, 8 Hudson North (Neurosurgery/Neurology)
  • Director, Psychiatric Neurosurgery Service


  • Spanish


  • Male

Credentials & Experience

Education & Training

  • MD, 2005 David Geffen School of Medicine at UCLA
  • 2005 David Geffen School of Medicine at UCLA
  • Residency: Massachusetts General Hospital
  • Fellowship: Massachusetts General Hospital


The Functional and Cognitive Neurophysiology laboratory, led by Dr. Sameer Sheth, focuses on the study of human decision-making, behavior, and cognitive processes. We use a combination of imaging and intracranial electrophysiology to investigate structural and functional relationships in the human brain. Neurosurgical procedures such as deep brain stimulation (DBS), epilepsy surgery, and brain tumor resection often require detailed imaging and electrophysiological recordings before, during, and after surgery. We utilize these unique opportunities to study the human brain and behavior in health and disease states.

Research Interests

  • Cortical and Basal Ganglia Networks involved in Disorders of Mental Health
  • Coupling between Neuronal Activity and Hemodynamics in Human Cortex
  • Novel Targets and Indications for Neuromodulation
  • Physiology of Human Cognitive Control

Selected Publications

Basic Science

Smith EH, Banks GP, Mikell CB, Cash SC, Patel SR, Eskandar EN, Sheth SA. "Frequency-dependent representation of reinforcement-related information in human medial and lateral prefrontal cortex." Journal of Neuroscience (2015 in press).

Banks G, Mikell CB, Youngerman BE, Henriques B, Kelly KM, Chan AK, Herrera D, Dougherty DD, Eskandar EN, Sheth SA. "Neuroanatomical predictors of response to dorsal anterior cingulotomy for obsessive-compulsive disorder." JAMA Psychiatry 72(2): 127-135 (2015).

McGovern, RA, Ratneswaren, T, Smith, EH, Russo, JF, Jongeling, AC, Bateman, LM, Schevon CA, Feldstein NF, McKhann GM, Sheth SA. Investigating the function of deep cortical and subcortical structures using stereotactic electroencephalography: lessons from the anterior cingulate cortex. Journal of Visualized Experiments : JoVE, (98). doi:10.3791/52773 (2015).

Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL, Kwon CS, Dougherty DD, Flaherty AW, Greenberg BD, Gale JT, Williams ZM, Eskandar EN. "Studying task-related activity of individual neurons in the human brain." Nature Protocols 8(5): 949-57 (2013).

Sheth SA, Mian MK, Patel SR, Asaad WF, Williams ZM, Dougherty DD, Bush G, Eskandar EN. "Human dorsal anterior cingulate neurons mediate ongoing behavioral adaptation." Nature 488: 218-221 (2012).

Patel S*, Sheth SA*, Mian MK, Gale JT, Greenberg BD, Dougherty DD, Eskandar EN. "Single-neuronal responses during a financial decision making task in the human nucleus accumbens." Journal of Neuroscience 32: 7311-7315 (2012). *Contributed equally.

Mian MK, Sheth SA, Patel SR, Spiliopoulos K, Eskandar EN, Williams ZW. "Encoding of rules by neurons in the human dorsolateral prefrontal cortex." Cerebral Cortex Nov 21 (2012 Epub ahead of print).

Sheth SA, Abuelem T, Gale JT, Eskandar EN. "Basal Ganglia Neurons Dynamically Facilitate Exploration during Associative Learning." Journal of Neuroscience 31(13): 4878-4885 (2011).


Brown, LT, Mikell, CB, Youngerman, BE, Zhang, Y, McKhann, GM, Sheth, SA Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies. Journal of Neurosurgery, 1-13. doi:10.3171/2015.1.JNS14681 (2015).

Russo JF, Sheth SA. "Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain." Neurosurgical Focus (2015 in press).

Sinha S, McGovern RA, Sheth SA. "Deep brain stimulation for severe autism: from pathophysiology to procedure." Neurosurgical Focus (2015 in press).

Sheth SA, Neal J, Tangherlini F, Mian MK, Dougherty D, Eskandar EN. "Limbic system surgery for treatment-refractory obsessive-compulsive disorder: five-year prospective follow-up in 64 patients." Journal of Neurosurgery 118: 491-97 (2012).