Qais Al-Awqati, MB, ChB

Board Certifications: 
Nephrology, Internal Medicine
Profile Headshot

Overview

Areas of Expertise / Conditions Treated

Hospitalist

Academic Appointments

  • Jay Meltzer Professor of Nephrology and Hypertension
  • Robert F. Loeb Professor of Medicine
  • Professor of Physiology & Cellular Biophysics

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Gender

  • Male

Location(s)

CUMC/Presbyterian Hospital and Vanderbilt Clinic
622 West 168th Street
New York, NY 10032
Primary

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • NYP Employee Plan
  • POS
  • PPO
  • Signature Administrators
  • Student Health

AgeWell

  • Medicare Managed Care
  • Special Needs Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Access (Exchange)
  • EPO
  • Gatekeeper (Exchange)
  • HMO
  • Medicare Managed Care
  • Pathway (Exchange)
  • POS
  • PPO

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Multiplan

  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • University of Baghdad College of Medicine (Iraq)
  • Residency: Baltimore City General Hospital - MD
  • Fellowship: Johns Hopkins Hospital

Board Certifications

  • Nephrology
  • Internal Medicine

Honors & Awards

  • 2005 Stevens Triennial Prize. Columbia University College of P & S.
  • 2005 Fellow,American Academy of Arts & Sciences
  • 2006 Distinguished Achievement Award University of Iowa, Dept of Medicine
  • 2007 Homer W. Smith Award; American Society of Nephrology
  • 2008 Ewig Clinical Scholar Award Columbia University, Dept of Medicine
  • 2009 The Harvey Lecture;The Harvey Society
  • 2010 Princess Liliane of Belgium Award Princess Liliane Foundation
  • 2010 Robert W Berliner Award. American Physiological Society, Renal Excellence in Renal Physiology Section

Research

Epithelial Differentiation
During development epithelia cells are generated from non-epithelial stem cells. These epithelia all have tight junction and apical and basal polarity. Mature epithelia however are easy to recognize as being tissue-specific. This implies that a second differentiation signal is needed to specify these terminally differentiated phenotypes. We have discovered a pathway for terminal differentiation of epithelia cells. Starting with a kidney cell line, we found that an extracellular matrix protein, which we termed hensin induces terminal differentiation in epithelial cells. This protein is expressed in most epithelia. Hensin requires to be localized in the matrix to bind to tis receptor. Knockout of hensin caused defects in the terminal differentiation of the earliest embryonic epithelia.

Kidney Development
During nephrogenesis, a set of mesenchyma cells convert to epithelia and then segment to form the nephron. We are studying the processes that generate and determine the segment identity and the number of nephrons.

Stem Cells
We have recently identified that the mature kidney contains stem cells. We are presently isolating these stem cells with a view towards characterizing their transcriptional program.

Research Interests

  • Epithelial Cell Biology
  • Kidney Development
  • Stem Cells

Grants

TRAINING MEDICAL STUDENTS IN NIDDK RESEARCH (Federal Gov)

May 1 2017 - Apr 30 2022

TERMINATION DIFFERENTIATION OF RENAL EPITHELIA: THE HENSIN P ATHWAY (Private)

Jul 1 2009 - Jun 30 2012

Selected Publications

  • Oliver JA, Barasch J, Yang J, Herzlinger D, Al-Awqati Q. (2002 ) Metanephric mesenchyme contains embryonic renal stem cells. Am J Physiol Renal Physiol 283(4):F799-809
  • Al-Awqati Q. (2003) Terminal differentiation of intercalated cells: the role of hensin. Annu Rev Physiol :567-83
  • Al-Awqati Q, Oliver JA. (2002) Stem cells in the kidney. Kidney Int 61(2):387-95
  • Schwartz GJ, Tsuruoka S, Vijayakumar S, Petrovic S, Mian A, Al-Awqati Q. (2002) Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. J Clin Invest 109(1):89-99
  • Hikita C, Vijayakumar S, Takito J, Erdjument-Bromage H, Tempst P, Al-Awqati Q. (2000) Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3. J Cell Biol 151(6):1235-46
  • Al-Awqati Q. (1999) One hundred years of membrane permeability: does Overton still rule? Nat Cell Biol 1(8):E201-2