Peter A. Sims, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Systems Biology (in Biochemistry and Molecular Biophysics and in Systems Biology)

Administrative Titles

  • Director, Columbia Single Cell Analysis Core
  • Director, Systems Biology Graduate Studies

Dr. Sims received in Ph.D. in chemistry from Harvard University where he also conducted postdoctoral research, and has been an Assistant Professor at Columbia since 2012. He has served as Director of Systems Biology Graduate Studies since 2016 and Director of the Columbia Single Cell Analysis Core since 2017.

Credentials & Experience

Education & Training

  • PhD, Chemistry, Harvard University

Research

The Sims Lab at Columbia University Medical Center focuses on the development of new technology for the application of systems biology in biomedicine. We recently developed and applied new experimental and computational methods for cell type-specific, genome-wide analysis of transcription and translation in complex tissues such as the brain. In addition, we have developed new technology for large-scale expression analysis of individual cells by combining cutting-edge microscopy, next-generation sequencing, and microfabrication. We apply these tools in several human disease contexts including brain tumors and other neurological disorders.

Grants

GENE EXPRESSION PROGRAMS IN MATURING DOPAMINE NEURONS: TEMPORAL REGULATION, SUBCELLULAR LOCALIZATION, AND ALTERATION BY AMPHETAMINE (Federal Gov)

Jan 1 2019 - Dec 31 2023

TISSUE COMPARTMENTALIZATION OF HUMAN LYMPHOCYTES (Federal Gov)

Jun 25 2018 - May 31 2023

IMMUNOBIOLOGY AND ALVEOLAR PHYSIOLOGY OF THE AGING LUNG (Federal Gov)

Jan 1 2019 - Dec 31 2022

SYSTEMATIC IDENTIFICATION AND PHARMACOLOGICAL TARGETING OF TUMOR DEPENDENCIES FOR PRECISION CANCER MEDICINE (Federal Gov)

Jul 1 2017 - Jul 31 2022

ELUCIDATING THE DEPENDENCIES OF TUMOR INITIATING AND DRUG-RESISTANT NICHES IN HUMAN MALIGNANCIES BY GENOME-WIDE MOLECULAR PROFILING OF SINGLE CELLS (Federal Gov)

Aug 14 2015 - Jul 31 2022

AN INTEGRATED MAP OF THE IMMUNE SYSTEM IN HUMANS ACROSS TISSUES AND AGES (Private)

Jul 1 2019 - Jun 30 2022

SINGLE CELL ANALYSIS OF THE INFILTRATIVE MARGINS OF GLIOBLASTOMA AND POST-TREATMENT RECURRENCE (Federal Gov)

Jul 1 2017 - Jun 30 2022

INTEGRATED IMAGING AND MOLECULAR ANALYSIS OF GLIOBLASTOMA USING SCOPE-SEQ ON THE AIR FLOW SYSTEM (Federal Gov)

Sep 16 2019 - Jun 15 2022

NOTCH IN ANGIOGENESIS AND VASCULAR BIOLOGY (Federal Gov)

Jan 1 2018 - Dec 31 2021

HUMAN ANTI-VIRAL IMMUNE RESPONSES IN TISSUES AND CIRCULATION (Federal Gov)

Jan 1 2017 - Dec 31 2021

NEW OPPORTUNITIES FOR MODELING DRUG RESPONSE IN SOLID TUMORS AFFORDED BY SINGLE-CELL GENOMICS (Private)

Dec 7 2018 - Dec 6 2021

CENTERS FOR CANCER SYSTEMS THERAPEUTICS (CAST) (Federal Gov)

Aug 8 2016 - Jul 31 2021

NOVEL GENOMIC AND TRANSCRIPTOMIC TOOLS TO STUDY HUMAN CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT (Federal Gov)

Sep 20 2018 - Jun 30 2021

TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

May 19 2015 - Apr 30 2021

LARGE-SCALE INTEGRATION OF SINGLE CELL RNA-SEQ AND HIGH-CONTENT IMAGING FOR ANALYZING DRUG RESPONSE IN CANCER (Federal Gov)

Apr 1 2016 - Mar 31 2020

PATHOLOGOMICS: ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATION (Federal Gov)

Feb 1 2015 - Jan 31 2020

FULLY INTEGRATED SINGLE CELL IMAGING AND RNA-SEQ LIBRARY PREPARATION (Federal Gov)

Dec 15 2017 - Nov 30 2019

THE GENETIC ORIGINS AND COMPLICATIONS OF URINARY TRACT ABNORMALITIES (Federal Gov)

Sep 24 2014 - Sep 24 2019

REDEFINING DM BY AGNOSTIC KIDNEY INTERROGATION: A PILOT GRANT IN CONFIRMATION OF SN-RNASEQ TECHNOLOGY (Federal Gov)

Nov 1 2017 - Oct 31 2018

MOLECULAR MECHANISMS UNDERLYING THE EPILEPTOGENESIS AND SEIZURE PROGRESSION IN TUBEROUS SCLEROSIS COMPLEX 1 DEFICIENT MOUSE MODELS (Federal Gov)

Sep 15 2015 - Sep 14 2018

COMPARATIVE STUDIES OF LARGE-SCALE SINGLE CELL SEQUENCING TECHNOLOGIES IN COMPLEX TISSUES WITH INTEGRATED ON-CHIP IMAGING (Private)

Sep 1 2017 - Aug 31 2018

TARGETING KIF11 TO TREAT GLIOBLASTOMA INVASION AND PROLIFERATION (Federal Gov)

Jul 1 2017 - Jun 30 2018

A MICROFLUIDIC SYSTEM FOR IMAGE-GUIDED RNA-SEQ OF SINGLE CELLS IN GLIOBLASTOMA (Federal Gov)

Sep 30 2012 - Aug 31 2017

MULTIPLEX RNA IMAGING IN SINGLE CELLS BY SUPERRESOLUTION MICROSCOPY AND BARCODE FISH (Federal Gov)

Jul 1 2016 - Jun 30 2017

NEURONAL TRANSLATION IN TSC2+/-AND FMR1-/Y MUTANT ASD MOUSE MODELS (Private)

Jul 1 2015 - Jun 30 2017

IDENTIFYING NOVEL GILOMA THERAPEUTIC TARGETS USING AN ECOSYSTEMS APPROACH (Federal Gov)

Sep 1 2015 - Aug 31 2016

SINGLE CELL STUDIES OF LINEAGE SPECIFIC EXPRESSION OF THE PROTOCADHERIN GENE CLUSTER (Federal Gov)

Jul 1 2014 - Jun 30 2016

GENE EXPRESSION CHANGES IN STRIATAL CHOLINERGIC INTERNEURONS ASSOCIATED WITH L-DOPA-INDUCED DYSKINESIA IN PD. (Private)

Aug 7 2014 - Aug 6 2015

MULTIPLEXED, SINGLE MOLECULE PROTEIN IDENTIFICATION FOR SINGLE CELL PROTEOMICS (Federal Gov)

Sep 30 2012 - Aug 31 2014

CELL TYPE-SPECIFIC PROFILING FOR AUTISM SPECTRUM DISORDERS (Private)

Dec 1 2012 - Nov 30 2013