Ottavio Arancio, MD, PhD
- Professor of Pathology and Cell Biology and of Medicine (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain)
Dr. Ottavio Arancio received his Ph.D and M.D. from the University of Pisa (Italy). From 1981 to 1986 he took residency training in Neurology at the University of Verona (Italy). Dr. Arancio has held Faculty appointments at Columbia University, NYU School of Medicine and at SUNY HSCB. In 2004 he became Faculty member of the Dept of Pathology & Cell Biology and The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain at Columbia University. His honors include the “G. Moruzzi Fellowship” (Georgetown University), the “Anna Villa Rusconi Foundation Prize” (Italy), the “INSERM Poste Vert Fellowship” (France), the AHAF centennial Award (2007), the Zenith Award (2007), the Margaret Cahn Research Award (2008), and the Edward N. and Della L. Thome Memorial Foundation Award (2010). Dr. Arancio is currently running the laboratory in Neurophysiology and Behavior of the Taub Institute. Over the last 10 years he raised more than $25 million in grant funding and published more than 100 peer reviewed manuscripts.
Dr Arancio is a cellular neurobiologist who has contributed to the characterization of the mechanisms of learning in both normal conditions and during neurodegenerative diseases. During the last ten years he has pioneered the field of mechanisms of synaptic dysfunction in Alzheimer’s disease. More recently he has established a shockwave exposure mouse model for the study of traumatic brain injury. Dr. Arancio’s laboratory has focused primarily on events triggered by oligomeric proteins including amyloid-beta and tau. These studies have suggested new links between synaptic dysfunction and dementia, both for understanding the etiopathogenesis of Alzheimer’ disease and traumatic brain injury, and for developing therapies aiming to improve the cognitive symptoms.
Dr. Arancio has been featured on "bigthink.com".
- Professor of Pathology and Cell Biology and of Medicine (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain)
Credentials & Experience
Education & Training
- MD, PhD, Medicine, University of Pisa (Italy)
Committees, Societies, Councils
Society for Neuroscience (USA)
1995-2000 New Zealand Neurological Foundation, Scientific Advisory Board (reviewed grant applications in the field of Neuroscience from Academic Institutions in New Zealand)
2000 - Present Italian Ministry of University, National Scientific Committee for Grant Evaluation (reviewed research projects as an external member of a national panel. Applications are in the field of Neuroscience and are submitted from Academic Institutions in Italy)
2001 - Present Alzheimer’s Association (reviewed international applications submitted to their annual research grants program)
2000 - Present Institute for the Study of Aging / Alzheimer’s Drug Discovery Foundation (member of their Scientific Review Board. Periodically reviewed international grant applications from Academia and Industry. Focus on drug discovery in aging and Alzheimer’s Disease)
2002 Philip Morris (reviewed grant applications in the field of neuroscience)
2002 “Ad hoc” expert EFSA GMO panel (to advise European Food Safety Authority which is responsible for evaluating the safety of all genetically modified foods).
2003 - Present NIH: served on the following drug discovery review groups (ZRG1 MDCN-C/MNPS-C, ZRG1 GGG-T), as well as review groups for P01s, and special emphasis panels
2004 - Present Wellcome Trust (reviewed grant applications. The Wellcome Trust is the largest charity in the UK funding innovative biomedical research, in the UK and internationally)
2004-2008 Human Frontier Science Program (reviewed grant applications for Post-Doctoral fellowships. The organization supports novel, innovative and interdisciplinary basic research focused on the complex mechanisms of living organisms. A clear emphasis is placed on novel collaborations that bring biologists together with scientists from fields such as physics, mathematics, chemistry, computer science and engineering to focus on problems at the frontier of the life sciences).
2006 - Present Science Foundation Ireland (reviewed for the Principal Investigator Programme Grant. The foundation was created by the Irish Government to invest significant funds in leading researchers working in fields of science and enginnering)
2007 - Present Medical Research Council (MRC) (reviewed grant applications for the New Investigator Awards. The MRC is funded by the UK Government and supports medical research in the UK)
2008 - Present National Medical Research Council (NMRC) (evaluated applications for Individual Research Grant. The NMRC is funded by the Government of Singapore and supports medical research in Singapore)
2008 - Present Alzheimer’s Society – UK (reviewed applications submitted to their annual research grants program)
2008 - 2012 Department of Veteran Affairs (served on the following review group: Neurobiology D)
2011 - Present Ministero della Salute (Italy) (evaluated applications for Individual Research Grant, Program Projects and Industry/Academia collaborations)
2011 European Research council (evaluated applications for Individual Research Grant)
2012 - Present Research Grant Council (RGC) of Hong Kong (evaluated applications for Individual Research Grant)
2012 Czech Scienze foundation (evaluated applications for Individual Research Grant)
2013 NSF (evaluated applications for Individual Research Grant)
2013 - Present The French National Research Agency (ANR) (evaluated applications for Individual Research Grant)
2013 - Present The Netherlands Organisation for Health Research and Development (evaluated applications for Individual Research Grant)
2013 - Present The W. Garfield Weston Foundation (evaluated applications for Individual Research Grant)
2014-2017 Society for Neuroscience Program Committee
Honors & Awards
- 1987 G. Moruzzi Fellowship, Fidia Research Foundation, Washington, D.C., USA
- 1990 Anna Villa Rusconi Foundation Prize, Varese, Italy
- 1990 Fellowship, Fidia SPA, Abano Terme, Italy
- 1991 Fellowship, Fidia SPA, Abano Terme, Italy
- 1991 INSERM Poste vert Fellowship, Paris, France
- 1994 Fellowship, University of Bologna, Bologna, Italy
- 2001-2003 Whitehead Fellowship
- 2001-2004 Speaker’s Fund for Biomedical Research
- 2004-2006 Investigator Initiated Research Award
- 2007 AHAF, Centennial Award
- 2007 Alzheimer’s Association, Zenith Award
- 2008 Margaret Cahn Research Award
- 2010 Edward N. and Della L. Thome Memorial Foundation, Award
Research in my laboratory stems from my life-long commitment to studying mechanisms of synaptic plasticity. I am interested in the cellular and molecular mechanisms that underlie long-lasting changes of synaptic function in both normal, healthy brains and in the brains of those affected by neurological disorders, in particular Alzheimer's disease (AD). Research in my laboratory focuses on the mechanisms by which oligoemric proteins including amyloid-β (Aβ) peptides and tau interfere with both memory formation and the regulation of hippocampal long-term potentiation (LTP), an activity-dependent model of synaptic plasticity that is thought to be related with learning and memory. I am interested in how regulation of gene activation and silencing, post-translational mechanisms, channel opening, intracellular calcium transients and changes in transmitter release machinery might participate in basal synaptic transmission and in synaptic plasticity.
- Biophysics/Ion Channels
- Neural Degeneration and Repair
- Neurobiology of Disease
- Neurobiology of Learning and Memory
- Synapses and Circuits
- Gnanaprakash M, Staniszewski A, Zhang H, Pitstick R, Kavanaugh MP, Arancio O, Nicholls RE. Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice. J Alzheimers Dis. 2021;79(4):1813-1829. PMID: 33459709
- Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM. Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction". J Med Chem. 2020 63:8649. PMID: 32672466
- Arancio O. What Does the APP Family Do in the Brain? Neuron. 108:583-585, 2020. PMID: 33242425
- Staniszewski A, Zhang H, Asam K, Pitstick R, Kavanaugh MP, Arancio O, Nicholls RE. Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice. J Neurosci. 40:4596-4608, 2020. PMID: 32341098.
- Puzzo D, Argyrousi EK, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, Acquarone E, Fa' M, Li Puma DD, Grassi C, D'Adamio L, Kanaan NM, Fraser PE, Arancio O. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. J Clin Invest. 130:4831-4844, 2020. PMID: 32544084.
- Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G. Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations. Autophagy. 2019 15:113-130. 1509818. PMID: 30160596.
- Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models. Nat Med. 2019 25:165-175. PMID: 30617325.
- Kelschenbach J, He H, Kim BH, Borjabad A, Gu CJ, Chao W, Do M, Sharer LR, Zhang H, Arancio O, Potash MJ, Volsky DJ. Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment. MBio. 2019 10. PMCID: PMC6606797.
- Gulisano W, Melone M, Ripoli C, Tropea MR, Li Puma DD, Giunta S, Cocco S, Marcotulli D, Origlia N, Palmeri A, Arancio O, Conti F, Grassi C, Puzzo D. Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory. J Neurosci. 2019 39:5986-6000.
- Acquarone E, Argyrousi EK, van den Berg M, Gulisano W, Fà M, Staniszewski A, Calcagno E, Zuccarello E, D'Adamio L, Deng SX, Puzzo D, Arancio O, Fiorito J. Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade. Mol Neurodegener. 2019 14:26. PMID: 31248451.
- Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM. A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. J Med Chem. 2019 62:5298-5311. PMID: 30978288.
- Fang F, Yu Q, Arancio O, Chen D, Gore SS, Yan SS, Yan SF. RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity. Hum Mol Genet. 2018 27:1002-1014. PMID: 29329433
- Yang S, Pascual-Guiral S, Ponce R, Giménez-Llort L, Baltrons MA, Arancio O, Palacio JR, Clos VM, Yuste VJ, Bayascas JR. Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides. Front Aging Neurosci. 2018 9:435. PMID: 29358916
- Biundo F, Del Prete D, Zhang H, Arancio O, D'Adamio L. A role for tau in learning, memory and synaptic plasticity. Sci Rep. 2018 8:3184. PMID: 29453339
- Evans LP, Newell EA, Mahajan M, Tsang SH, Ferguson PJ, Mahoney J, Hue CD, Vogel EW 3rd, Morrison B 3rd, Arancio O, Nichols R, Bassuk AG, Mahajan VB. Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice. Ann Clin Transl Neurol. 2018 5:240-251. PMID: 29560370
- Gu CJ, Borjabad A, Hadas E, Kelschenbach J, Kim BH, Chao W, Arancio O, Suh J, Polsky B, McMillan J, Edagwa B, Gendelman HE, Potash MJ, Volsky DJ. EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. PLoS Pathog. 2018 14:e1007061. PMID: 29879225.
- Gulisano W, Tropea MR, Arancio O, Palmeri A, Puzzo D. Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease. Neuropharmacology. 2018 138:151-159. PMID: 29885420
- Argyrousi EK, Staniszewski A, Nicholls RE, Arancio O. Preparation of Tau Oligomers After the Protein Extraction from Bacteria and Brain Cortices. Methods Mol Biol. 2018 1779:85-97. PMID: 29886529.
- Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse. Alzheimers Dement (N Y). 2018 4:37-45. PMID: 29955650.
- Rutigliano G, Stazi M, Arancio O, Watterson DM, Origlia N. An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease. Neurobiol Aging. 2018 70:86-91. PMID: 30007168.
- Gulisano W, Melone M, Li Puma DD, Tropea MR, Palmeri A, Arancio O, Grassi C, Conti F, Puzzo D. The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status. Neurobiol Aging. 2018 71:51-60. PMID: 30092511.
- Ricciarelli R, Brullo C, Prickaerts J, Arancio O, Villa C, Rebosio C, Calcagno E, Balbi M, van Hagen BT, Argyrousi EK, Zhang H, Pronzato MA, Bruno O, Fedele. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease. Sci Rep. 2017 7:46320. PMCID: PMC5389348.
- Manassero G, Guglielmotto M, Monteleone D, Vasciaveo V, Butenko O, Tamagno E, Arancio O, Tabaton M. Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice. J Alzheimers Dis. 2017 59:743-751. PMID: 28671129.
- Piacentini R, Li Puma DD, Mainardi M, Lazzarino G, Tavazzi B, Arancio O, Grassi C. Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons. Glia. 2017 65:1302-1316. PMCID: PMC5520670.
- Puzzo D, Piacentini R, Fá M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O. LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent. Elife. 2017 6. pii: e26991. PMCID: PMC5529106.
- Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE. SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model. Neurobiol Dis. 2017 110:154-165. PMID: 29217476
- Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L. Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations. Transl Psychiatry. 2017 7:e1198. PMID: 28786980
- Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR. Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits. Acta Neuropathol. 2017 134:749-767. PMID: 28631094
- Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory. J Neurosci. 2017 37:6926-6937. PMID: 28626017.
- Martín-Maestro P, Gargini R, A Sproul A, García E, Antón LC, Noggle S, Arancio O, Avila J, García-Escudero V. Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. Front Mol Neurosci. 2017 10:291. PMID: 2895918.
- Fiorito J, Vendome J, Saeed F, Staniszewski A, Zhang H, Yan S, Deng SX, Arancio O, Landry DW. Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease. J Med Chem. 2017 60:8858-8875. PMID: 28985058
- Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons. Acta Neuropathol Commun. 2017 5:77. PMID:29078805
- Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. PLoS One. 2017 12:e0189413. PMID: 29253878
- Koppensteiner P, Trinchese F, FÃ M, Puzzo D, Gulisano W, Yan S, Poussin A, Liu S, Orozco I, Dale E, Teich AF, Palmeri A, Ninan I, Boehm S, Arancio O. Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease. Sci Rep. 2016 6:32553. PMCID: PMC5007504
- Brullo C, Ricciarelli R, Prickaerts J, Arancio O, Massa M, Rotolo C, Romussi A, Rebosio C, Marengo B, Pronzato MA, van Hagen BT, van Goethem NP, D'Ursi P, Orro A, Milanesi L, Guariento S, Cichero E, Fossa P, Fedele E, Bruno O. New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment. Eur J Med Chem. 2016 124:82-102. PMID: 27560284
- Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016 15:914-23. PMCID: PMC5013016
- Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Mol Neurodegener. 2016 11:35, PMCID: PMC4850651
- Teich AF, Sakurai M, Patel M, Holman C, Saeed F, Fiorito J, Arancio O. PDE5 exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease. J Alzheimers Dis., 2106 Mar 9. [Epub ahead of print] PMID: 26967220.
- Nicholls, R.E., Sontag, J-M., Zhang, H., Staniszewski, A., Yan, S., Kim, C.Y., Yim, M., Woodruff, C.M., Arning, E., Wasek, B., Yin, D., Bottiglieri, T., Sontag, E., Kandel, E.R., Arancio, O., PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments. Proc. Natl. Acad. Sci. U S A, 2016 113:3347-52. PMCID: PMC4812727.
- FÃ¡ M., Puzzo D., Piacentini R., Staniszewski A., Zhang H., Baltrons M.A., Li Puma D.D., Chatterjee I., Li J., Saeed F., Berman H.L., Ripoli C., Gulisano W., Gonzalez J., Tian H., Costa J.A., Lopez P., Davidowitz E., Yu W.H., Haroutunian V., Brown L.M., Palmeri A., Sigurdsson E.M., Duff K.E., Teich A.F., Honig L.S., Sierks M., Moe J.G., D'Adamio L., Grassi C., Kanaan N.M., Fraser P.E., Arancio O. Extracellular tau oligomers produce an immediate impairment of LTP and memory. Sci Rep. 2016 6: 19393. PMCID: PMC4726138
- Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Ben Aissa M, FÃ M, Arancio O, Yue L, Pepperberg DR, Thatcher GR. Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia. BMC Neurosci. 2015 16:67. PMID: 26480871.
- FÃ M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. J Alzheimers Dis. 2015 49:707-21. PMID: 26484927.
- Hue CD, Cho FS, Cao S, Nicholls RE, Vogel Iii EW, Sibindi C, Arancio O, Bass C', Meaney D, Morrison III B 3rd. Time Course and Size of Blood-Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury. J Neurotrauma. 2015 Sep 28. [Epub ahead of print]. PMID: 26414212
- Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, Sosunov AA, McKhann GM, Chen JX, Yan SS. Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model. Hum Mol Genet. 2015 24: 5198-210. PMID: 26123488
- Matsuzaki S, Lee L, Knock E, Srikumar T, Sakurai M, Hazrati LN, Katayama T, Staniszewski A, Raught B, Arancio O, Fraser PE. SUMO1 Affects Synaptic Function, Spine Density and Memory. Sci Rep. 2015 5: 10730. PMID: 26022678
- Puzzo D, Gulisano W, Palmeri A, Arancio O. (2015). Rodent models for Alzheimer's disease drug discovery. Expert opinion on drug discovery. 10:703-711.
- Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, et al. (2015). Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS chemical neuroscience. 6:666-680.
- Kim S, Titcombe RF, Zhang H, Khatri L, Girma HK, et al. (2015) . Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. 112:3122-127.
- Nestor MW, Jacob S, Sun B, PrÃ¨ D, Sproul AA, et al. (2015). Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies. American journal of physiology. Cell physiology. 308:C209-219.
- Teich AF, Nicholls RE, Puzzo D, Fiorito J, Purgatorio R, et al. (2015). Synaptic therapy in Alzheimer's disease: a CREB-centric approach. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 12:29-41.
- Lee L, Dale E, Staniszewski A, Zhang H, Saeed F, et al. (2014). Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease. Scientific reports. 4:7190.
- Koppensteiner P, Boehm S, Arancio O. (2014). Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion.
- Cellular reprogramming. 16:439-446.
- Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, et al. (2014). Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy. 10:1827-1843.
- Yan S, Li Z, Li H, Arancio O, Zhang W. (2014). Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation.
- Scientific reports. 4:6352.
- Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, et al. (2014). Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 83:1131-1143.
- Ren H, Yan S, Zhang B, Lu TY, Arancio O, et al. (2014). Glut4 expression defines an insulin-sensitive hypothalamic neuronal population. Molecular metabolism. 3:452-459.
- Origlia N, Criscuolo C, Arancio O, Yan SS, Domenici L. (2014). RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment.
- The Journal of neuroscience: the official journal of the Society for Neuroscience. 34:8749-8760.
- Puzzo D, Lee L, Palmeri A, Calabrese G, Arancio O. (2014). Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines. Biochemical pharmacology. 88:450-467.
- Ricciarelli R, Puzzo D, Bruno O, Canepa E, Gardella E, et al. (2014). A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
- Annals of neurology. 75:602-607.
- Puzzo D, Loreto C, Giunta S, Musumeci G, Frasca G, et al. (2014). Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiology of aging. 35:520-531.
- PrÃ¨ D, Nestor MW, Sproul AA, Jacob S, Koppensteiner P, et al. (2014). A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). PloS one. 9:e103418.
- FÃ M, Staniszewski A, Saeed F, Francis YI, Arancio O. (2014). Dynamin 1 is required for memory formation. PloS one. 9:e91954.
- Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, et al. (2014). Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PloS one. 9:e111898.
- Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, et al. (2014). Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PloS one. 9:e111899.
- Lee L, Kosuri P, Arancio O. (2014). Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. Journal of Alzheimer's disease : JAD. 38:49-62. NIHMSID: NIHMS595742.
- Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, et al. (2014). Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. PloS one. 9:e84547.
- Orozco IJ, Koppensteiner P, Ninan I, Arancio O. (2014). The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice. Molecular and cellular neurosciences. 58:76-84.
- Lee L, Sakurai M, Matsuzaki S, Arancio O, Fraser P. (2013). SUMO and Alzheimer's disease.
- Neuromolecular medicine. 15:720-36.
- Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, et al. (2013). Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.
- Journal of medicinal chemistry. 56:6054-68.
- Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, et al. (2013). Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of aging. 34:2052-2063.
- Fiorito J, Saeed F, Zhang H, Staniszewski A, Feng Y, et al. (2013). Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 60:285-294.
- Xing L, Salas M, Zhang H, Gittler J, Ludwig T, et al. (2013). Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).
- Mammalian genome : official journal of the International Mammalian Genome Society. 24:30-43.
- Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O, et al. (2013). Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nature communications. 4:1939.
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