Jahar Bhattacharya

Overview

Dr. Jahar Bhattacharya, MD, DPhil, Professor of Medicine, is the Director of Lung Research at the Division of Pulmonary and Critical Care Medicine at the CUMC. He has been a researcher for over thirty years with an interest in the biology of acute lung injury. Dr. Bhattacharya graduated in medicine from the Institute of Medical Sciences (AIIMS), New Delhi, India. He was cardiology resident at the Radcliff Infirmary, Oxford, UK. Subsequently, he obtained a Ph.D. from Oxford University, and then completed his postdoctoral training at the Cardiovascular Research Institute, University of California at San Francisco. Dr. Bhattacharya's research has been supported by NIH funding and he has served on multiple NIH study sections both as permanent and ad hoc member. He serves as member of Advisory Board for the Cardiopulmonary System, Universities of Giessen, Frankfurt and Max-Planck Inst., Germany and as reviewer for multiple journals. He served on the Executive Committee of the APS Respiration Section and was Chair of the Pulmonary Circulation Assembly of the American Thoracic Society. He has given invited lectures at national and international meetings and has won awards including the Rhodes Scholarship, the American Thoracic Society's Research Recognition Award, the MERIT award of the NIH, and the Julius Comroe award of the American Physiological Society. Ongoing projects in the Bhattacharya lab continue to be focused on basic mechanisms of acute lung injury and include optical imaging studies of macrophage-epithelial interactions, mitochondrial transfer between cells, lung procoagulant mechanisms, endothelial barrier biophysics and therapeutic effectiveness of cell-penetrating peptides. Dr. Bhattacharya directs the PACC’s T32 training program.

Credentials & Experience

Honors & Awards

1970 Rhodes Scholar
1973 Schorstein Lecturer, Oxford University
1976 F.L. Neizer Fellow, Stanford University
1985 NIH Research Career Development Award
1998 NIH MERIT Award
2001 American Thoracic Society (ATS) Award for Recognition of Scientific Accomplishments
2007 Chair, Pulmonary Circulation Assembly, ATS
2007 Member, Advisory Board, Excellence Cluster for the Cardiopulmonary System, Universities of Giessen, Frankfurt and Max-Planck Inst., Germany
2008 Chair, Columbia branch of Lung Research program at University of Giessen,Germany
2010 Reviewer, CSR College of Distinguished Reviewers, NHLBI
2010 Member of Advisory Board, Max Planck Institute, Bad Nauheim, Germany

Research

Selected Publications

Quadri, S. and J. Bhattacharya. Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007; 292:L334-42.
 
Lindert, J, Parthasarathi K, and Bhattacharya, J. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am. J. Resp. Cell. Mol. Biol.
 
2007. 36:688-96.
 
Perlman, CE and J. Bhattacharya. Alveolar micromechanics determined by optical sectioning microscopy. J. Appl. Physiol. 2007; 103:1037-44.
 
Bertuglia, S, Ichimura H, Fossati G, Parthasarathi K, Leoni F, Modena D, Cremonesi P, Bhattacharya J, and P. Mascagni. ITF1697, a stable Lys-Pro–containing peptide, inhibits
 
Weibel Palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 2007;13:615-24.
 
Kiefmann R, Rifkind JM, Nagababu E, and J Bhattacharya. RBC induce hypoxic lung inflammation. Blood. 2008. 111:5205-14.
 
Editorial Comment: G. Zimmerman. “Hypoxic erythrocytes spark lung leukocyte adhesion”.
 
Azeloglu EU, J Bhattacharya and KD Costa. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. J Appl Physiol. 2008;105:652-61
 
Otsu K, S Das, SD Houser, SK Quadri, S Bhattacharya and J Bhattacharya. Concentration dependent inhibition of angiogenesis by mesenchymal stem cells. Blood. 2009; 113:4197-205.
 
[Comment: M. Matthay. “Mesenchymally stemming angiogenesis”]
 
Lederer DJ, S Jelic, RC Basner, A Ishizaka, and J Bhattacharya. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnea. Eur. Respir. J. 2009; 33: 793-796.
 
Kiefmann R, MN Islam, J Lindert, K Parthasarathi, and J Bhattacharya. Paracrine purinergic signaling determines lung endothelial nitric oxide production. Am. J. Physiol. Lung Cell Mol. Physiol. 2009. 296:L901-10.
 
Perlman, CE, J Lindert and J. Bhattacharya. The micromechanics of alveolar edema. Am. J. Resp. Cell. Mol. Biol. (In Press).