Ivaylo Ivanov, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Microbiology & Immunology

Dr. Ivaylo (Ivo) Ivanov is an Assistant Professor at the Department of Microbiology and Immunology at Columbia University. Dr. Ivanov earned his Ph.D. on B cell repertoire diversification from The University of Alabama at Birmingham. He performed his postdoctoral training in the laboratory of Dan Littman at New York University, working on immunomodulatory effects of the gut microbiota. Dr. Ivanov is a recipient of an NIH Pathway to Independence Award, Crohn’s and Colitis Foundation (CCF) Young Investigator Award, a CCF Senior Research Award, and the Columbia University Schaefer Award for excellence in medical research. Dr. Ivanov is also a Pew Scholar in the Biomedical Sciences, sponsored by the Pew Charitable Trust and a recipient of a Pew Innovator Fund Award.

Credentials & Experience

Education & Training

  • PhD, 2004 B cell immunology, University of Alabama at Birmingham
  • Fellowship: 2010 New York University Langone Medical Center

Honors & Awards

  • 2017 Pew Charitable Trust Innovator Award
  • 2016 Schaefer Research Scholar Award for Excellence in Human Physiology
  • 2013 Crohn’s and Colitis Foundation of America Senior Research Award
  • 2012 Pew Scholar in Biomedical Sciences
  • 2010 NIH Pathway to Independence Award
  • 2009 Crohn’s and Colitis Foundation of America Career Development Award
  • 2007 Crohn’s and Colitis Foundation of America Young Investigator Award

Research

Commensal microbes have profound influence on human health, including metabolism, behavior, tumorigenesis, and immunity. My laboratory studies the immune mechanisms involved in recognition of commensal microbes and how these mechanisms participate in immune homeostasis (health) or immune pathology (disease). The two overarching research directions of the lab are to study 1) the cellular and molecular mechanisms by which resident commensal microbes engage and regulate host immunity and 2) the cellular networks that control immune responses in intestinal tissues.

Research Interests

  • mucosal immunity
  • microbiota effects on host physiology
  • host-microbe interactions
  • inflammatory bowel disease

Grants

MECHANISMS OF MUCOSAL TH17 CELL INDUCTION BY SEGMENTED FILAMENTOUS BACTERIA (Federal Gov)

Apr 15 2013 - Aug 31 2023

NON-REDUNDANT FUNCTIONS OF TYPE 3 INNATE LYMPHOID CELLS IN MUCOSAL IMMUNITY (Federal Gov)

Apr 1 2019 - Mar 31 2023

ALOPECIA AREATA CENTER FOR RESEARCH TRANSLATION (AACORT) (Federal Gov)

Sep 1 2016 - Jan 31 2022

DISCOVERY OF IMMUNOMODULATORY GUT MICROBES WITH MAGIC (Federal Gov)

Jun 3 2019 - May 31 2021

STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A NEW CLASS OF HOST-MICROBE INTERACTION (Private)

Nov 1 2017 - Oct 31 2020

NEW MECHANISM OF COMMENSAL BACTERIA INTERACTION WITH HOST IMMUNITY (Federal Gov)

Feb 1 2017 - Jan 31 2020

MECHANISMS OF TH17 CELL INDUCTION BY SEGMENTED FILAMENTOUS BACTERIA (Private)

Aug 1 2012 - Dec 31 2017

IN SITU GENOME ENGINEERING OF UNCULTURABLE MICROBES AND GENOMIC RECORDING TO LIMIT THE ROBUSTNESS OF THE GENETIC CODE (Federal Gov)

Jul 1 2015 - Sep 30 2016

THE ROLE OF TH17 CELL INDUCED BY COMMENSAL BACTERIA IN THE INDUCTION OF CHRONIC INFLAMMATION (Private)

Jul 1 2014 - Mar 31 2015

ROLE OF INTESTINAL ANTIGEN PRESENTING CELL SUBSETS IN TH17 CELL INDUCTION BY COMMENSAL BACTERIA (Private)

Nov 1 2013 - Jun 30 2014

THE ROLE OF TH CELLS INDUCED BY COMMENSAL BACTERA IN THE INDUCTIONS OF CHRONIC INFLAMMATION (Private)

Jul 31 2013 - Mar 31 2014

REGULATION OF MUCOSAL TH17 CELL RESPONSE BY INTESTINAL BACTERIA (Federal Gov)

Jan 1 2011 - Dec 31 2013

ROLE OF RORYT+ TH17 CELLS IN INTESTINAL INFLAMMATION AND IMMUNITY (Private)

Jul 1 2012 - Jun 30 2013

Selected Publications

  1. Ivanov II. Microbe Hunting Hits Home. Cell Host & Microbe 2017, Mar 8;21(3):282-285. PMID 28279331
  2. Ivanov II. Mucosal Bioengineering: Gut in a Dish. Trends in Immunology 2017, Jul 3, In Press. PMID 28684208
  3. Panea C, Farkas AM, Goto Y, Abdollahi-Roodsaz S, Lee C, Koscso B, Gowda K, Hohl TM, Bogunovic M, Ivanov II. Intestinal monocyte-derived macrophages control commensal antigen-specific Th17 responses.Cell Reports 2015, Aug 25;12(8):1314-24. PMID 26279572
  4. Goto Y, Panea C, Nakato G, Cebula A, Lee C, Diez MG, Laufer TM, Ignatowicz L, Ivanov II. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 2014, Apr 17; 40(4):594-607. PMID: 24684957
  5. Goto Y and Ivanov II. Intestinal epithelial cells as mediators of the commensal-host immune crosstalk. Immunology and Cell Biology 2013, Mar;91(3):204-14. PMID: 23318659
  6. Ivanov II and Honda K. Intestinal commensal microbes as immune modulators. Cell Host and Microbe 2012, Oct 18;12(4):496-508. PMID: 23084918
  7. Sczesnak A, Segata N, Qin, X, Gevers D, Petrosino JF, Huttenhower C, Littman DR and Ivanov II. The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe 2011, Sep 15;10(3):260-72. PMID: 21925113.
  8. Ivanov II and Littman DR. Modulation of immune homeostasis by commensal bacteria. Current Opinions in Microbiology 2011 Jan 5. PMID: 21215684
  9. Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010 June 17; 32(6): 815-827
  10. Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009 Oct 30; 139:1-14. PMID: 19836068
  11. Luci C*, Reynders A*, Ivanov II*, Cognet C, Chasson L, Hardwigsen J, Anguiano E, Banchereau J, Chaussabel D, Dalod M, Littman DR, Vivier E, Tomasello E. Differential roles of the transcription factor RORgt in the development of NKp46+ lymphoid-tissue inducer-like cells and NKp46+ natural killer cells in gut and skin. Nature Immunology 2009 Jan; 10(1):75-82. PMID: 19029904 (*equal contribution)
  12. Ivanov II, Frutos RL, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host and Microbe 2008, 4(4):337-49. PMID: 18854238
  13. Ivanov II, Zhou L, and Littman DR. Transcriptional regulation of Th17 cell differentiation. Seminars in Immunology 2007, 19(6):409-17
  14. Ivanov II, McKenzie BS, Zhou L, Tadokoro C, Lepelley A, Lafaille JJ, Cua DJ, Littman DR.  The orphan nuclear receptor RORgt directs the differentiation program of pro-inflammatory IL-17+ T helper cells. Cell 2006, 126(6):1121-33
  15. Ivanov II, Diehl GE, and Littman DR. Lymphoid Tissue Inducer Cells in Intestinal Immunity.  Curr Top Microbiol Immunol 2006, 308:59-82
  16. II Ivanov, RL Schelonka, Y Zhuang, GL Gartland, M Zemlin, and HW Schroeder, Jr.. Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge, that are first established in early B cell progenitors.  The Journal of Immunology 2005, 174:7773-7780
  17. Ivanov II, Link JM, Ippolito GC and Schroeder HW, Jr.. Constraints on the Hydropathicity and Sequence Composition of HCDR3 are Conserved Across Evolution. In The Antibodies 2002, 7:43-67.  Ed. by Zanetti M & Capra JD