Gary Struhl, PhD

Profile Headshot

Overview

Academic Appointments

  • Professor of Genetics and Development (in Neuroscience)

Administrative Titles

  • Principal Investigator at Columbia's Zuckerman Institute

Gender

  • Male

Credentials & Experience

Honors & Awards

American Academy of Arts and Sciences Member (2005)

National Academy of Sciences Member (2008)

Research

Developmental genetics in Drosophila.

During development, cells are programmed to generate and interpret spatial information so that every cell within a population knows where it is and what to do as a consequence. Dr. Struhl's work uses genetical and molecular approaches in Drosophila to address the fundamental questions (i) what is spatial information?, (ii) how is it generated?, and (iii) how is it interpreted? His work has led to discoveries about the nature and mode action of spatial determinants controlling cell and body patterns, tissue growth and planar cell polarity. These include (i) the Polycomb and HOX “selectors” in specifying body segments; (ii) the transcription and translation factors Bicoid, Caudal, Hunchback and Nanos in organizing global body pattern, (iii) secreted factors of the Hedgehog, Wnt, and BMP/TGFb superfamilies as the first, intercellular gradient morphogens, (iv) Delta/Notch signaling in cell-fate specification, and (v) the serpentine receptors Frizzled and Starry night, and the atypical cadherins Dachsous and Fat, in planar cell polarity.

Zuckerman Institute: https://zuckermaninstitute.columbia.edu/gary-struhl-phd

Struhl Lab: https://struhl-lab.zuckermaninstitute.columbia.edu/

Research Interests

  • Cell-cell signaling
  • Cell patterning
  • Organ growth

Grants

THE MECHANISM OF NOTCH ACTIVATION BY EPSIN-DEPENDENT LIGAND ENDYCYTOSIS IN DROSOPHILA

5RO1GM109183-04

Project Dates: Sep 1 2014 to May 31 2018

CONTROL OF DROSOPHILA WING GROWTH BY MORPHOGEN

1R35GM127141

Project Dates: May 1, 2018 to April 31 2023

Selected Publications

  1. Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch  proteins. Langridge PD et al. Curr. Biol. 2022 Mar 23
  2. A unified mechanism for mechanism for the control of Drosophila wing growth by the morphogens Decapentaplegic and Wingless. Zecca M, Struhl G. PLoS Biol. 2021 Mar 3
  3. Control of Drosophila wing size by morphogen range and hormonal gating. Parker, J, Struhl, G. Proc. Natn. Acad. Sci. U.S.A. 2020 Dec 15
  4. Epsin-dependent ligand endocytosis activates Notch by force. Langridge PD, Struhl G. Cell.2017 Nov 30
  5. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Coleman RT, Struhl G. Science.2017 Mar 16
  6. Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts. Vrabioiu AM, Struhl G. Dev Cell.2015 Dec 21
  7. A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. Zecca M, Struhl G. PLoS Biol.2010 Jun 1