Aristidis Floratos, PhD

Profile Navigation

Overview

Academic Appointments

  • Assistant Professor of Biomedical Informatics (in the Department of Systems Biology)

Administrative Titles

  • Director, Systems Biology
  • Director, Biomedical Informatics Shared Resource
  • Executive Research Director, Center for Computational Biology and Bioinformatics

Aris Floratos is an assistant professor in the Department of Biomedical Informatics and executive research director at the Center for Computational Biology and Bioinformatics. His lab develops collaborative bioinformatics software to support the analysis and visualization of genomic data from a wide range of domains (gene expression, sequence, protein structure, and systems biology). This software leverages standards-based middleware technologies to provide seamless access to remote data, annotation, and computational servers, enabling researchers with limited local resources to benefit from public infrastructure. The Floratos Lab is also developing innovative, systems biology-driven methodologies that offer improved power to detect the contribution of low-risk genetic factors to drug-induced serious adverse events (SAEs). In collaboration with an international network of investigators, the lab is leading the analysis of genome-wide genotyping and exome sequencing data for drug-induced disorders including serious skin rash, liver injury, cardiac arrhythmias, and osteonecrosis of the jaw. Finally, the Floratos Lab has developed motif discovery algorithms that have been used to study the underlying evolutionary architecture of genomic sequences.

Research

Grants

SYSTEMATIC IDENTIFICATION AND PHARMACOLOGICAL TARGETING OF TUMOR DEPENDENCIES FOR PRECISION CANCER MEDICINE (Federal Gov)

Jul 1 2017 - Jul 31 2022

ALOPECIA AREATA CENTER FOR RESEARCH TRANSLATION (AACORT) (Federal Gov)

Sep 1 2016 - Jan 31 2022

HUMAN ANTI-VIRAL IMMUNE RESPONSES IN TISSUES AND CIRCULATION (Federal Gov)

Jan 1 2017 - Dec 31 2021

RECEPTORS IN ENDOSOMES MEDIATE CHRONIC PAIN ASSOCIATED WITH TRAUMA AND STRESS: NON-OPIOID TARGETS FOR PAIN (Federal Gov)

Sep 1 2018 - Aug 31 2021

CENTERS FOR CANCER SYSTEMS THERAPEUTICS (CAST) (Federal Gov)

Aug 8 2016 - Jul 31 2021

CLINICAL AND TRANSLATIONAL SCIENCE AWARD (Federal Gov)

Jul 1 2016 - May 31 2021

BIOMEDICAL DATA TRANSLATOR TECHNICAL FEASIBILITY ASSESSMENT AND ARCHITECTURE DESIGN (Federal Gov)

Sep 25 2016 - Dec 31 2019

CANCER CENTER SUPPORT GRANT (Federal Gov)

Jul 1 2014 - Jun 30 2019

DENGUE HUMAN IMMUNOLOGY PROJECT CONSORTIUM (DHIPC) (Federal Gov)

Jun 1 2017 - May 31 2019

SYSTEMS BIOLOGY OF TUMOR PROGRESSION AND DRUG RESISTANCE (Federal Gov)

Jun 1 2012 - Apr 30 2018

DATA COORDINATION CENTER FOR SERIOUS ADVERSE EVENT CONSORTIUM (Private)

Jul 1 2010 - Dec 31 2017

NATIONAL CENTER: MULTISCALE ANALYSIS OF GENOMIC AND CELLULAR NETWORKS (MAGNET) (Federal Gov)

Sep 26 2005 - Jul 31 2016

CLINICAL AND TRANSLATIONAL SCIENCE AWARD (UL1) (Federal Gov)

Sep 30 2006 - Jun 30 2016

INTEGRATIVE ANALYSIS GENOMIC AND PROTEOMIC DATA FROM THE CANCER GENOME ATLAS (Federal Gov)

Feb 1 2015 - Jan 31 2016

IDENTIFICATION OF SUSCEPTIBILITY GENES FOR ESSENTIAL TREMOR (Federal Gov)

Sep 15 2011 - Jul 31 2015

PROFILING SIGNATURES OF SYNERGISTIC CHEMICAL PERTURBATIONS IN DIVERSE CELLULAR C (Federal Gov)

Sep 16 2011 - Aug 31 2014

A SYSTEMS APPROACH TO ELUCIDATE MECHANISMS OF DRUG ACTIVITY AND SENSITIVITY USING LINCS DATA (Federal Gov)

Sep 24 2011 - Jun 30 2014

DATA COORDINATION CENTER FOR SERIOUS ADVERSE EVENT CONSORTIUM (Private)

Jul 1 2010 - Mar 30 2014

DATA COORDINATION CENTER FOR SERIOUS ADVERSE EVENT CONSORTIUM (Private)

Jul 1 2010 - Mar 30 2014

SAIC FREDERICK (Federal Gov)

Sep 1 2012 - Sep 30 2013

PROPOSAL FOR DATA SHARING & ANALYSIS INFRASTRUCTURE FOR P2 ALS PROJECT (Private)

Sep 15 2011 - Sep 14 2013

2009 CABIG IN SILICO RESEARCH CENTERS OF EXCELLENCE (Federal Gov)

Sep 15 2009 - Sep 14 2012

CABIG KNOWLEDGE CENTER FOR MOLECULAR ANALYSIS TOOLS (GEWORKBENCH, GENEPATTERN, CAINTEGRATOR) (Federal Gov)

Jun 2 2008 - Jun 1 2012